Evaluating the Specificity of [18f]ucb-h for the Isoform Sv2a, Compared with Sv2b and Sv2c
نویسندگان
چکیده
These results allow us to conclude that [18F]UCB-H is a suitable radiotracer for the imaging of the isoform SV2A in vivo. Forty male Sprague-Dawley were divided in two experiments SV2A is a SV2 isoform protein involved in the synaptic vesicle trafficking and in brain process like the epilepsy (1, 2). [18F]UCB-H was developed like a tool to study the role of this isoform with neuroimaging techniques (3, 4).
منابع مشابه
SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment.
Synaptic vesicle protein 2 (SV2) is expressed in neuroendocrine cells as three homologous isoforms, SV2A, SV2B and SV2C. Ca2+-dependent function in exocytosis has been attributed to SV2A and SV2B, without elucidation of the mechanism. The role of SV2C has not yet been addressed. Here we characterize the three SV2 isoforms and define their involvement in regulated insulin secretion. SV2A and SV2...
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